MDMA 70Mg + MDA 25Mg + Cialis 2.5Mg
MDMA (3,4-Methylenedioxy-N-methylamphetamine) is unique from just about every other compound on this list. Its effects are universally-loved; it’s even being pursued as a medical treatment for conditions such as PTSD and depression and as a tool for couples therapy.
MAPS (the Multidisciplinary Association for Psychedelic Studies) has been leading the charge for legalizing MDMA. The group has been organizing Phase I, II, and III clinical trials for decades and recently submitted a protocol to the FDA to bring MDMA back into clinical therapy.
The effects of MDMA are strongly empathogenic — more so than any other compound on this list. It’s considered a psychedelic because it interacts with the 5HT2A receptors (same target for LSD, psilocybin, and DMT) — albeit to a lesser extent.
MDMA primarily targets the dopamine (D1 and D2) receptors and 5HT2B (serotonin) receptors
MDA (3,4-methylenedioxyamphetamine) — sometimes referred to as “Sass” — is closely related to MDMA and is one of the primary metabolites formed as MDMA is broken down by the liver [13].
MDA was invented in 1910 but wasn’t used in medicine until the 1960s where is prescribed as an appetite suppressant under the name Tenamfetamine. It’s no longer used in medicine and is classified as a Schedule I restricted substance or equivalent globally.
This compound is rarely used intentionally as a recreational drug but is a common adulterant in ecstasy tablets. It’s much easier to make than MDMA and produces similar — albeit less desirable — effects than MDMA. MDA is considered weaker, shorter-lasting, and more likely to result in side effects than MDMA. It also has a stronger intoxicating effect than MDMA — rather than feeling more clear-headed, MDA makes users feel a sort of stimulant drunk. Disinhibition is common in higher doses, which can lead users to do things they later regret.
MDA acts as a serotonin-norepinephrine–dopamine releasing agent (SNDRA) to produce its characteristic effects.